Herpes Simplex Keratitis

Statistics and Associations

  • Most common cause of central infectious keratitis
  • Occurs secondary to reactivation of HSV type I through nervous system
  • Following one HSK infection, 25% chance of recurrence in one year; 50% chance of recurrence in two years
  • Suppressive therapy reduces risk of recurrent keratitis by almost 50%


  • Topical antiviral (Viroptic™ q2h or Zirgan™ 5xday) for two weeks, oral antiviral (valacyclovir 500 mg PO TID) for one week.
  • Consider suppressive therapy (valacyclovir 500 mg QD) for recurrent cases